1........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340..
hemo-tunicate-1 ----M-------------------------------P---------------------------------------------------------------FTDEELKLLRDSWDEVK--KLGM---KEVGLHIFTGLLNAAPSLRTLFYTIDLPD--E--EE----L-TIDVMRENKKVVAHATRIANAISKFIKFLD---Q-PDELEKLLTS---LGESH-ARRQ---V-DPESFEYVAPVILSVIGGH-----LKLPSNSPTLQAWVKA----YGVLRNGIVS---AM-----------EA----------------------------------------
hemo-tunicate-3 ----M-------------------------------S---------------------------------------------------------------LTSEQVVLLRSSWQTIG--KLGM---SNVGLAVLHRLFNDVPETLPFFHSVLSP---T--QQ----T-EIEVLKSNAKVVRHASRVGLSIDKIINLLD---N-GEELVKYLLF---LGQVH-VKRS---I-PRKYFSAMGPVLLSVISAV-----LEKDLDAPVMQAWATA----YGVIEQGIID---GM-----------------------------------------------------
hemo-polychaete-4 ----M-------------------------------G---------------------------------------------------------------LSAAQRQVVASTWKDIAGSD-NG---AGVGKECFTKFLSAHHDIAAVFG--------F--SG----A-S------DPGVADLGAKVLAQIGVAVSHLG---D-EGKMVAEMKA---VGVRH-KGYGYKHI-KAEYFEPLGASLLSAMEHR-----IGGKMTAAAKDAWAAA----YADISGALIS---GL---------QS------------------------------------------
myo-polychaete ----MA------------------------------G---------------------------------------------------------------LSGADIAVIRSTWAKVQGSG-SA---TDIGRSIFIKFFELDPAAQNEFP--------C--KG----E-SLAALKTNVLLGQHGAKFMEYITTAVNGLD---DYAGKAHGPLTE---LGSRH-KTRG---T-TPANFGKAGEALLAILASV-----VGGDFTPAAKDAWTKV----YNTISSTMQA---AL-----------------------------------------------------
leghemo-pea ----M-------------------------------G---------------------------------------------------------------FTEKQEALVNSSWELFK--Q-NP---SY-SVLFYTIILKKAPAAKGMFS--------F--LK----D-SA-EVVDSPKLQAHAEKVFGMVHDSAIQLR---A-SGEVVLGDAT---LGAIH-IQKG---V-VDPHFVVVKEALLETIKEA-----SGEKWSEELSTAWEVA----YEGLASAIKK---AM-------------N---------------------------------------
leghemo-rice ----M-------------------------------A---------------------------LVEDNNAVAVS-------------------------FSEEQEALVLKSWAILK--K-DS---ANIALRFFLKIFEVAPSASQMFS--------F--LR----N-SDVPLEKNPKLKTHAMSVFVMTCEAAAQLR---K-AGKVTVRDTTLKRLGATH-LKYG---V-GDAHFEVVKFALLDTIKEEV----PADMWSPAMKSAWSEA----YDHLVAAIKQ---EM-------------KPAE------------------------------------
neuro-human ----M-------------------------------E--------------------------------------------------------------R---PEPELIRQSWRAVS--R-SP---LEHGTVLFARLFALEPDLLPLFQ--------Y--NC-RQFS-SPEDCLSSPEFLDHIRKVMLVIDAAVTNVE---D-LSSLEEYLAS---LGRKH-RAVG---V-KLSSFSTVGESLLYMLEKC-----LGPAFTPATRAAWSQL----YGAVVQAMSR---GW--DGE------------------------------------------------
neuro-zebrafish ----M-------------------------------E--------------------------------------------------------------KLSEKDKGLIRDSWESLG--K-NK---VPHGIVLFTRLFELDPALLTLFS--------YSTNC----G-DAPECLSSPEFLEHVTKVMLVIDAAVSHLD---D-LHTLEDFLLN---LGRKH-QAVG---V-NTQSFALVGESLLYMLQSS-----LGPAYTTSLRQAWLTM----YSIVVSAMTR---GWAKNGEHKSN--------------------------------------------
HbA-blood_clam ----M-------------------------------A---------------------------------------------DEEQIAKAVFKEAKALC-DSDAAKENLRSSFKILA--N-DI---ESSGLQLMKNLFTSHPDTLGYFA------R-F--KD----V-SLG--KQNWQLRGHAITLMYALMNFVDALD---E-PDRLKCVVLK---FAVNH-NNRS---I-SPQVFGKINGPMDLLLKQR-----MGKYYNRETANAWKQL----VGVVQAALTT---PN-----------------------------------------------------
HbI-Lucina ----M-------------------------------S---------------------------------------------------------------LSAAQKDNVKSSWAKAS--A-AW---GTAGPEFFMALFDAHDDVFAKFS------GLF--KG----A-AKGTVKNTPEMAAQAQSFKGLVSNWVDNLD---N-AGALEGQCKT---FAANH-KARG---I-SAGQLEAAFKVLAGFMKSY-----------GGDEGAWTAV----AGALMGMIRP---NM-----------------------------------------------------
HbII-Lucina ----T-------------------------------T---------------------------------------------------------------LTNPQKAAIRSSWSKFM--D-NG---VSNGQGFYMDLFKAHPETLTPFK------SLF--GG----L-TLAQLQDNPKMKAQSLVFCNGMSSFVDHLD---D--NMLVVLIQK---MAKLH-NNRG---I-RASDLRTAYDILIHYMEDH-NHMV------GGAKDAWEVF----VGFICKTLGD---YM-------------------------------------------------KELS
myo-Dolabella ------------------------------------A---------------------------------------------------------------LSAAEAEVVAKSWGPVF--A-NK---DANGDNFLIALFEAYPDSPNFFA------D-F--KG----K-SIADIRASPKLRNVSSRIVSRLNEFVSSAA---D-AGKMAAMLDQ---FSKEH-AGFG---V-GSQQFQNVSAMFPGFVASI-------AAPPAGADAAWGKL----FGLIIDAMKK--AGK-----------------------------------------------------
myo-snail ------------------------------------S---------------------------------------------------------------LQPASKSALASSWKTLA--K-DAATIQNNGATLFSLLFKQFPDTRNYFT------H-F--GN----M-SDAEMKTTGVGKAHSMAVFAGIGSMIDSMD---D-ADCMNGLALK---LSRNH-IQRK---I-GASRFGEMRQVFPNFLDEA-----LGGGASGDVKGAWDAL----LAYLQDNKQA--QAL-----------------------------------------------------
drosophila ----M------------------------------------------------------------------------------------------------NSDEVQLIKKTWEIPV--A-TP---TDSGAAILTQFFNRFPSNLEKFP--------F--RD----V-PLEELSGNARFRAHAGRIIRVFDESIQVLGQDGD-LEKLDEIWTK---IAVSH-IPRT---V-SKESYNQLKGVILDVLTAA-----CSLDES--QAATWAKLVDHVYAIIFKAIDDDG-NA-----------------------------------------------------
midge-8 AVTPM------------------------------------------------------------------------------------------------SADQLALFKSSWNTVK--H-NE-------VDILYAVFKANPDIQAKFP------Q-F--AG----K-DLDSIKDSADFAVHSGRIVGFFSEVIGLIGNPEN-RPALKTLIDG---LASSH-KARG---I-EKAQFEEFRASLVDYLSHH-----LDWNDT--MKSTWDLALNNMFFYILHALEV---AQ-----------------------------------------------------
honeybee ----M-GTFLRFLGISSSDDNRIDQAT---------G---------------------------------------------------------------LTERQKKLVQNTWAVVR--K-DE---VASGIAVMTAFFKKYPEYQRYFT------A-F--MD----T-PLNELPANKRFQAHCAGVITALNNVIDFLH---D-PGLMEASLIG---LVERH-KKRG---Q-TKEEFQNLKEVMLEVLRQA-----LGKQYTPEVAEAWNKTLDMMFGKIYQVFAS----------------------------------------------------------
beetle ----M-GQLISLYKYYTTRTDDPDPLT---------T---------------------------------------------------------------LTSREVFLVQSSWDPIK--K-DL---TGYGVQLLLFLFKKYPEEQQNFP--------F--RD----M-PFEELGASKKFHAHCSNVMYAVDSIIDSLK---D-GELLVNILEK---IGRNH-HRNT---V-KPISFWHVKETMLEFFKKM-----M----NDETLKAWDKALQVAFGVVAKELDK---KN-----------------------------------------------------
cyto-beetle ----M-GIITSTLSYYMTKTNDPDPIT---------G---------------------------------------------------------------LTSRDRYVIQTSWAPVK--K-DL---TGNGVALLLLYFEKFPATKNYFV--------F--KD----V-PNEKLKTDKKFHAHCNSVMVTLDSLIANLN---D-GELIVSLLEK---LGKNH-KRHG---I-KDDAYDQLKETVIELFSSF-----M----TKEELETWDKLLKVAFSVIIKYL------------------------------------------------------------
myo-human ----M-------------------------------G---------------------------------------------------------------LSDGEWQLVLNVWGKVE--A-DI---PGHGQEVLIRLFKGHPETLEKFD------K-F--KH----LKSEDEMKASEDLKKHGATVLTALGGILKKKG---H----HEAEIKP---LAQSHATKHK---I-PVKYLEFISECIIQVLQSK-----HPGDFGADAQGAMNKA----LELFRKDMAS---NY-----------------KELGFQG-----------------------------
myo-shark -------------------------------------------------------------------------------------------------------VDWEKVNSVWSAVE--S-DL---TAIGQNILLRLFEQYPESQNHFP------K-F--KN-----KSLGELKDTADIKAQADTVLSALGNIVKKKG---S----HSQPVKA---LAATHITTHK---I-PPHYFTKITTIAVDVLSEM-----YPSEMNAQVQAAFSGA----FKIICSDIEK---EY-----------------KAANFQG-----------------------------
cyto-fish ----M-------------------------------SHREPPPPQLAVQRRDVDGQDGPERAEP------------------------------------LSDTEREMIRDAWGHVY--K-NC---EDVGVSILIRFFVNFPSAKQYFS------Q-F--QD----MEEPEEMERSSQLRHHACRVMNALNTVVENLH---D-PEKVSSVLAV---VGRAHAVKHK---V-EPMYFKILSGVILEVLCED-----FPEFFTADVQLVWSKL----MATVYWHVTG---AY------------------------TDVGWLQ-----------VSSSAV-----
cyto-human ----M----------------------------------EKVPGEMEIERR--------ERSEE------------------------------------LSEAERKAVQAMWARLY--A-NC---EDVGVAILVRFFVNFPSAKQYFS------Q-F--KH----MEDPLEMERSPQLRKHACRVMGALNTVVENLH---D-PDKVSSVLAL---VGKAHALKHK---V-EPVYFKILSGVILEVVAEE-----FASDFPPETQRAWAKL----RGLIYSHVTA---AY------------------------KEVGWVQQVPNATTPPATLPSSGP-----
hagfish ----M-------------------------------S---------------------------------------AHGIAR------------------TTEGERAAVRASWAVLM--K-DY---EHAGVQILDKFFKANPAAKPFFT------K-M--KD----LHTLEDLASSADARWHVERIIQAVNFAVINIE---D-REKLSNKFVK---LSQDHIEEFH---VTDPQYFMILSQTILDEVEKR------NGGLSGEGKSGWHKV----MTIICKMLKS---KY-----------------------------------------------------
lamprey ----M----------------------PIVDSGSVPA---------------------------------------------------------------LTAAEKATIRTAWAPVY--A-KY---QSTGVDILIKFFTSNPAAQAFFP------K-F--QG----LTSADQLKKSMDVRWHAERIINAVNDAVVAMD---D-TEKMSLKLRE---LSGKHAKSFQ---V-DPQYFKVLAAVIVDTV--------LPGD------AGLEKL----MSMICILLRS---SY-----------------------------------------------------
hemo-alpha-human ----M-------------------------------V---------------------------------------------------------------LSPADKTNVKAAWGKVG--A-HA---GEYGAEALERMFLSFPTTKTYFP------H-F---D----LSH-----GSAQVKGHGKKVADALTNAVAHVD---D----MPNALSA---LSDLHAHKLR---V-DPVNFKLLSHCLLVTLAAH-----LPAEFTPAVHASLDKF----LASVSTVLTS---KY------------------------------------------------R----
hemo-alpha-shark ------------------------------------V---------------------------------------------------------------LSAADKTAIKHLTGSLR--T-NA---EAWGAESLARMFATTPSTKTYFS------K-F--TD----FSA-----NGKRVKAHGGKVLNAVADATDHLD---N----VAGHLDP---LAVLHGTTLC---V-DPHNFPLLTQCILVTLAAH-----L-TELKPETHCALDKF----LCEVATALGS---HY------------------------------------------------R----
hemo-beta-human ----M-------------------------------V--------------------------------------H------------------------LTPEEKSAVTALWGKV-----NV---DEVGGEALGRLLVVYPWTQRFFE------S-F--GD----LSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLD---N----LKGTFAT---LSELHCDKLH---V-DPENFRLLGNVLVCVLAHH-----FGKEFTPPVQAAYQKV----VAGVANALAH---KY------------------------------------------------H----
hemo-beta-shark ------------------------------------V--------------------------------------H------------------------WTGEEKALVNAVWTKT-----DH---QAVVAKALERLFVVYPWTKTYFV------K-F--NGK---FHASD-----STVQTHAGKVVSALTVAYNHID---D----VKPHFVE---LSKKHYEELH---V-DPENFKLLANCLEVELGHA-----LHKEFTPEVQAAWSKF----SNVVVDALSK---GY------------------------------------------------H----