1........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350
hemo-tunicate-1 ????M???????????????????????????????P???????????????????????????????????????????????????????????????FTDEELKLLRDSWDEVK??K?LG???MKEVGLHIFTGLLNAAPSLRTLF??????Y?T???I????DLPD?????EEELTIDVMRENKKVVAHATRIA???N????AISKFIK???FLDQPDELEK???L?LTSLGESHARRQVDPESFE?????YVAPVILSVIGGHLKLPSNSPTLQAWVKAYGVLRNG??IV?SAMEA---????-------???????------------------------?????
hemo-tunicate-3 ????M???????????????????????????????S???????????????????????????????????????????????????????????????LTSEQVVLLRSSWQTIG??K?LG???MSNVGLAVLHRLFNDVPETLPFF??????H?S???V????LSPT?????QQTEIEVLKSNAKVVRHASRVGL???S????IDKIINL???LDNGEELVKY???L?LFLGQVHVKRSIPRKYFSA?????MGPVLLSVISAVLEKDLDAPVMQAWATAYGVIEQGI??ID?GM------????-------???????------------------------?????
hemo-polychaete-4 ????M???????????????????????????????G???????????????????????????????????????????????????????????????LSAAQRQVVASTWKDIA??G?SD???NGAGVGKECFTKFLSAHHDIAAV??????F?G???F????SGAS?????DPGVADLGAKVLAQIGVAVSHLG???D????EGKMVAE???MKAVGVRHKG???Y?GYKHIKAEYFEPLGASLLS?????AMEHRIGGKMTAAAKDAWAAAYADISGALISGLQS-??--?--------????-------???????------------------------?????
myo-polychaete ????M???????????????????????????????A???????????????????????????????????????????????????????????????GLSGADIAVIRSTWAKV??Q?GS???GSATDIGRSIFIKFFELDPAAQN??????E?F???P????CKGE?????SLAALKTNVLLGQHGAKFMEYIT???T????AVNGLDD???YAGKAHGPLT???E?LGSRHKTRGTTPANFGKAG?????EALLAILASVVGGDFTPAAKDAWTKVYNTISSTMQA??AL?--------????-------???????------------------------?????
leghemo-pea ????M???????????????????????????????G???????????????????????????????????????????????????????????????FTEKQEALVNSSWELFK??Q?NP???SYSVLFYTIILKKAPAAKGMFSF??????L?K???D????SAEV?????VDSPKLQAHAEKVFGMVHDSAIQ???L????RASGEVV???LGDATLGAIH???I?QKGVVDPHFVVVKEALLET?????IKEASGEKWSEELSTAWEVAYEGLASAIKKAMN---??--?--------????-------???????------------------------?????
leghemo-rice ????M???????????????????????????????A???????????????????????????????????????????????????????????????LVEDNNAVAVSFSEEQE??A?LV???LKSWAILKKDSANIALRFFLKIF??????E?V???A????PSAS?????QMFSFLRNSDVPLEKNPKLKTHA???M????SVFVMTC???EAAAQLRKAG???K?VTVRDTTLKRLGATHLKYG?????VGDAHFEVVKFALLDTIKEEVPADMWSPAMKSAWSE??AY?DHLVAAIK????QEMKPAE???????------------------------?????
neuro-human ????M???????????????????????????????E???????????????????????????????????????????????????????????????RPEPELIRQSWRAVSRS??P?LE???HGTVLFARLFALEPDLLPLFQYN??????C?R???Q????FSSP?????EDCLSSPEFLDHIRKVMLVIDAA???V????TNVEDLS???SLEEYLASLG???R?KHRAVGVKLSSFSTVGESL?????LYMLEKCLGPAFTPATRAAWSQLYGAVVQAMSRGWD??GE?--------????-------???????------------------------?????
neuro-zebrafish ????M???????????????????????????????E???????????????????????????????????????????????????????????????KLSEKDKGLIRDSWESL??G?KN???KVPHGIVLFTRLFELDPALLTLF??????S?Y???S????TNCG?????DAPECLSSPEFLEHVTKVMLVID???A????AVSHLDD???LHTLEDFLLN???L?GRKHQAVGVNTQSFALVGE?????SLLYMLQSSLGPAYTTSLRQAWLTMYSIVVSAMTRG??WA?KNGEHKSN????-------???????------------------------?????
HbA-blood_clam ????M???????????????????????????????A???????????????????????????????????????????????????????????????DEEQIAKAVFKEAKALC??D?SD???AAKENLRSSFKILANDIESSGLQ??????L?M???K????NLFT?????SHPDTLGYFARFKDVSLGKQNWQ???L????RGHAITL???MYALMNFVDA???L?DEPDRLKCVVLKFAVNHNN?????RSISPQVFGKINGPMDLLLKQRMGKYYNRETANAWK??QL?VGVVQAAL????TTPN---???????------------------------?????
HbI-Lucina ????M???????????????????????????????S???????????????????????????????????????????????????????????????LSAAQKDNVKSSWAKAS??A?AW???GTAGPEFFMALFDAHDDVFAKFS??????G?L???F????KGAA?????KGTVKNTPEMAAQAQSFKGLVSN???W????VDNLDNA???GALEGQCKTF???A?ANHKARGISAGQLEAAFKV?????LAGFMKSYGGDEGAWTAVAGALMGMIRPNM------??--?--------????-------???????------------------------?????
HbII-Lucina ????T???????????????????????????????T???????????????????????????????????????????????????????????????LTNPQKAAIRSSWSKFM??D?NG???VSNGQGFYMDLFKAHPETLTPFK??????S?L???F????GGLT?????LAQLQDNPKMKAQSLVFCNGMSS???F????VDHLDDN???MLVVLIQKMA???K?LHNNRGIRASDLRTAYDIL?????IHYMEDHNHMVGGAKDAWEVFVGFICKTLGDYMKEL??S-?--------????-------???????------------------------?????
myo-Dolabella ????A???????????????????????????????L???????????????????????????????????????????????????????????????SAAEAEVVAKSWGPVFA??N?KD???ANGDNFLIALFEAYPDSPNFFAD??????F?K???G????KSIA?????DIRASPKLRNVSSRIVSRLNEFV???S????SAADAGK???MAAMLDQFSK???E?HAGFGVGSQQFQNVSAMFP?????GFVASIAAPPAGADAAWGKLFGLIIDAMKKAGK---??--?--------????-------???????------------------------?????
myo-snail ????S???????????????????????????????L???????????????????????????????????????????????????????????????QPASKSALASSWKTLAK??D?AA???TIQNNGATLFSLLFKQFPDTRNY??????F?T???H????FGNM?????SDAEMKTTGVGKAHSMAVFAGIG???S????MIDSMDD???ADCMNGLALK???L?SRNHIQRKIGASRFGEMRQ?????VFPNFLDEALGGGASGDVKGAWDALLAYLQDNKQAQ??AL?--------????-------???????------------------------?????
drosophila ????M???????????????????????????????N???????????????????????????????????????????????????????????????SDEVQLIKKTWEIPVAT??P?TD???SGAAILTQFFNRFPSNLEKFPFR??????D?V???P????LEEL?????SGNARFRAHAGRIIRVFDESIQV???L????GQDGDLE???KLDEIWTKIA???V?SHIPRTVSKESYNQLKGVI?????LDVLTAACSLDESQAATWAKLVDHVYAIIFKAIDDD??GN?A-------????-------???????------------------------?????
midge-8 ????A???????????????????????????????V???????????????????????????????????????????????????????????????TPMSADQLALFKSSWNT??V?KH???NEVDILYAVFKANPDIQAKFPQF??????A?G???K????DLDS?????IKDSADFAVHSGRIVGFFSEVIG???L????IGNPENR???PALKTLIDGL???A?SSHKARGIEKAQFEEFRAS?????LVDYLSHHLDWNDTMKSTWDLALNNMFFYILHALEV??AQ?--------????-------???????------------------------?????
honeybee ????M???????????????????????????????G???????????????????????????????????????????????????????????????TFLRFLGISSSDDNRID??Q?AT???GLTERQKKLVQNTWAVVRKDEVA??????S?G???I????AVMT?????AFFKKYPEYQRYFTAFMDTPLNE???L????PANKRFQ???AHCAGVITAL???N?NVIDFLHDPGLMEASLIGL?????VERHKKRGQTKEEFQNLKEVMLEVLRQALGKQYTPE??VA?EAWNKTLD????MMFGKIY???????QVFAS-------------------?????
beetle ????M???????????????????????????????G???????????????????????????????????????????????????????????????QLISLYKYYTTRTDDPD??P?LT???TLTSREVFLVQSSWDPIKKDLTG??????Y?G???V????QLLL?????FLFKKYPEEQQNFPFRDMPFEEL???G????ASKKFHA???HCSNVMYAVD???S?IIDSLKDGELLVNILEKIG?????RNHHRNTVKPISFWHVKETMLEFFKKMMNDETLKAW??DK?ALQVAFGV????VAKELDK???????KN----------------------?????
cyto-beetle ????M???????????????????????????????G???????????????????????????????????????????????????????????????IITSTLSYYMTKTNDPD??P?IT???GLTSRDRYVIQTSWAPVKKDLTG??????N?G???V????ALLL?????LYFEKFPATKNYFVFKDVPNEKL???K????TDKKFHA???HCNSVMVTLD???S?LIANLNDGELIVSLLEKLG?????KNHKRHGIKDDAYDQLKETVIELFSSFMTKEELETW??DK?LLKVAFSV????IIKYL--???????------------------------?????
myo-human ????M???????????????????????????????G???????????????????????????????????????????????????????????????LSDGEWQLVLNVWGKVE??A?DI???PGHGQEVLIRLFKGHPETLEKFD??????K?F???K????HLKS?????EDEMKASEDLKKHGATVLTALGG???I????LKKKGHH???EAEIKPLAQS???H?ATKHKIPVKYLEFISECII?????QVLQSKHPGDFGADAQGAMNKALELFRKDMASNYKE??LG?FQG-----????-------???????------------------------?????
myo-shark ????V???????????????????????????????D???????????????????????????????????????????????????????????????WEKVNSVWSAVESDLTA??I?GQ???NILLRLFEQYPESQNHFPKFKNK??????S?L???G????ELKD?????TADIKAQADTVLSALGNIVKKKG???S????HSQPVKA???LAATHITTHK???I?PPHYFTKITTIAVDVLSEM?????YPSEMNAQVQAAFSGAFKIICSDIEKEYKAANFQG-??--?--------????-------???????------------------------?????
cyto-fish ????M???????????????????????????????S???????????????????????????????????????????????????????????????HREPPPPQLAVQRRDVD??G?QD???GPERAEPLSDTEREMIRDAWGHV??????Y?K???N????CEDV?????GVSILIRFFVNFPSAKQYFSQFQ???D????MEEPEEM???ERSSQLRHHA???C?RVMNALNTVVENLHDPEKV?????SSVLAVVGRAHAVKHKVEPMYFKILSGVILEVLCED??FP?EFFTADVQ????LVWSKLM???????ATVYWHVTGAYTDVGWLQVSSSAV?????
cyto-human ????M???????????????????????????????E???????????????????????????????????????????????????????????????KVPGEMEIERRERSEEL??S?EA???ERKAVQAMWARLYANCEDVGVAI??????L?V???R????FFVN?????FPSAKQYFSQFKHMEDPLEMERS???P????QLRKHAC???RVMGALNTVV???E?NLHDPDKVSSVLALVGKAH?????ALKHKVEPVYFKILSGVILEVVAEEFASDFPPETQR??AW?AKLRGLIY????SHVTAAY???????KEVGWVQQVPNATTPPATLPSSGP?????
hagfish ????M???????????????????????????????S???????????????????????????????????????????????????????????????AHGIARTTEGERAAVRA??S?WA???VLMKDYEHAGVQILDKFFKANPA??????A?K???P????FFTK?????MKDLHTLEDLASSADARWHVERI???I????QAVNFAV???INIEDREKLS???N?KFVKLSQDHIEEFHVTDPQ?????YFMILSQTILDEVEKRNGGLSGEGKSGWHKVMTIIC??KM?LKSKY---????-------???????------------------------?????
lamprey ????M???????????????????????????????P???????????????????????????????????????????????????????????????IVDSGSVPALTAAEKAT??I?RT???AWAPVYAKYQSTGVDILIKFFTS??????N?P???A????AQAF?????FPKFQGLTSADQLKKSMDVRWHA???E????RIINAVN???DAVVAMDDTE???K?MSLKLRELSGKHAKSFQVD?????PQYFKVLAAVIVDTVLPGDAGLEKLMSMICILLRSS??Y-?--------????-------???????------------------------?????
hemo-alpha-human ????M???????????????????????????????V???????????????????????????????????????????????????????????????LSPADKTNVKAAWGKVG??A?HA???GEYGAEALERMFLSFPTTKTYFP??????H?F???D????LSHG?????SAQVKGHGKKVADALTNAVAHVD???D????MPNALSA???LSDLHAHKLR???V?DPVNFKLLSHCLLVTLAAH?????LPAEFTPAVHASLDKFLASVSTVLTSKYR-------??--?--------????-------???????------------------------?????
hemo-alpha-shark ????V???????????????????????????????L???????????????????????????????????????????????????????????????SAADKTAIKHLTGSLRT??N?AE???AWGAESLARMFATTPSTKTYFSK??????F?T???D????FSAN?????GKRVKAHGGKVLNAVADATDHLD???N????VAGHLDP???LAVLHGTTLC???V?DPHNFPLLTQCILVTLAAH?????LTELKPETHCALDKFLCEVATALGSHYR--------??--?--------????-------???????------------------------?????
hemo-beta-human ????M???????????????????????????????V???????????????????????????????????????????????????????????????HLTPEEKSAVTALWGKV??N?VD???EVGGEALGRLLVVYPWTQRFFES??????F?G???D????LSTP?????DAVMGNPKVKAHGKKVLGAFSDG???L????AHLDNLK???GTFATLSELH???C?DKLHVDPENFRLLGNVLVC?????VLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH--??--?--------????-------???????------------------------?????
hemo-beta-shark ????V???????????????????????????????H???????????????????????????????????????????????????????????????WTGEEKALVNAVWTKTD??H?QA???VVAKALERLFVVYPWTKTYFVKF??????N?G???K????FHAS?????DSTVQTHAGKVVSALTVAYNHID???D????VKPHFVE???LSKKHYEELH???V?DPENFKLLANCLEVELGHA?????LHKEFTPEVQAAWSKFSNVVVDALSKGYH-------??--?--------????-------???????------------------------?????
???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????
hemo-tunicate-12 ----M-------------------------------P---------------------------------------------------------------FTDEELKLLRDSWDEVK--KLGM---KEVGLHIFTGLLNAAPSLRTLFYTIDLPD--E--EE----L-TIDVMRENKKVVAHATRIANAISKFIKFLD---Q-PDELEKLLTS---LGESH-ARRQ---V-DPESFEYVAPVILSVIGGH-----LKLPSNSP?????TLQAWVKA----YGVLRNGIVS---AM-----------EA???----------------------------------------
hemo-tunicate-32 ----M-------------------------------S---------------------------------------------------------------LTSEQVVLLRSSWQTIG--KLGM---SNVGLAVLHRLFNDVPETLPFFHSVLSP---T--QQ----T-EIEVLKSNAKVVRHASRVGLSIDKIINLLD---N-GEELVKYLLF---LGQVH-VKRS---I-PRKYFSAMGPVLLSVISAV-----LEKDLDAP?????VMQAWATA----YGVIEQGIID---GM-------------???----------------------------------------
hemo-polychaete-42 ----M-------------------------------G---------------------------------------------------------------LSAAQRQVVASTWKDIAGSD-NG---AGVGKECFTKFLSAHHDIAAVFG--------F--SG----A-S------DPGVADLGAKVLAQIGVAVSHLG---D-EGKMVAEMKA---VGVRH-KGYGYKHI-KAEYFEPLGASLLSAMEHR-----IGGKMTAA?????AKDAWAAA----YADISGALIS---GL---------QS--???----------------------------------------
myo-polychaete2 ----MA------------------------------G---------------------------------------------------------------LSGADIAVIRSTWAKVQGSG-SA---TDIGRSIFIKFFELDPAAQNEFP--------C--KG----E-SLAALKTNVLLGQHGAKFMEYITTAVNGLD---DYAGKAHGPLTE---LGSRH-KTRG---T-TPANFGKAGEALLAILASV-----VGGDFTPA?????AKDAWTKV----YNTISSTMQA---AL-------------???----------------------------------------
leghemo-pea2 ----M-------------------------------G---------------------------------------------------------------FTEKQEALVNSSWELFK--Q-NP---SY-SVLFYTIILKKAPAAKGMFS--------F--LK----D-SA-EVVDSPKLQAHAEKVFGMVHDSAIQLR---A-SGEVVLGDAT---LGAIH-IQKG---V-VDPHFVVVKEALLETIKEA-----SGEKWSEE?????LSTAWEVA----YEGLASAIKK---AM-------------???N---------------------------------------
leghemo-rice2 ----M-------------------------------A---------------------------LVEDNNAVAVS-------------------------FSEEQEALVLKSWAILK--K-DS---ANIALRFFLKIFEVAPSASQMFS--------F--LR----N-SDVPLEKNPKLKTHAMSVFVMTCEAAAQLR---K-AGKVTVRDTTLKRLGATH-LKYG---V-GDAHFEVVKFALLDTIKEEV----PADMWSPA?????MKSAWSEA----YDHLVAAIKQ---EM-------------???KPAE------------------------------------
neuro-human2 ----M-------------------------------E--------------------------------------------------------------R---PEPELIRQSWRAVS--R-SP---LEHGTVLFARLFALEPDLLPLFQ--------Y--NC-RQFS-SPEDCLSSPEFLDHIRKVMLVIDAAVTNVE---D-LSSLEEYLAS---LGRKH-RAVG---V-KLSSFSTVGESLLYMLEKC-----LGPAFTPA?????TRAAWSQL----YGAVVQAMSR---GW--DGE--------???----------------------------------------
neuro-zebrafish2 ----M-------------------------------E--------------------------------------------------------------KLSEKDKGLIRDSWESLG--K-NK---VPHGIVLFTRLFELDPALLTLFS--------YSTNC----G-DAPECLSSPEFLEHVTKVMLVIDAAVSHLD---D-LHTLEDFLLN---LGRKH-QAVG---V-NTQSFALVGESLLYMLQSS-----LGPAYTTS?????LRQAWLTM----YSIVVSAMTR---GWAKNGEHKSN----???----------------------------------------
HbA-blood_clam2 ----M-------------------------------A---------------------------------------------DEEQIAKAVFKEAKALC-DSDAAKENLRSSFKILA--N-DI---ESSGLQLMKNLFTSHPDTLGYFA------R-F--KD----V-SLG--KQNWQLRGHAITLMYALMNFVDALD---E-PDRLKCVVLK---FAVNH-NNRS---I-SPQVFGKINGPMDLLLKQR-----MGKYYNRE?????TANAWKQL----VGVVQAALTT---PN-------------???----------------------------------------
HbI-Lucina2 ----M-------------------------------S---------------------------------------------------------------LSAAQKDNVKSSWAKAS--A-AW---GTAGPEFFMALFDAHDDVFAKFS------GLF--KG----A-AKGTVKNTPEMAAQAQSFKGLVSNWVDNLD---N-AGALEGQCKT---FAANH-KARG---I-SAGQLEAAFKVLAGFMKSY-----------GG?????DEGAWTAV----AGALMGMIRP---NM-------------???----------------------------------------
HbII-Lucina2 ----T-------------------------------T---------------------------------------------------------------LTNPQKAAIRSSWSKFM--D-NG---VSNGQGFYMDLFKAHPETLTPFK------SLF--GG----L-TLAQLQDNPKMKAQSLVFCNGMSSFVDHLD---D--NMLVVLIQK---MAKLH-NNRG---I-RASDLRTAYDILIHYMEDH-NHMV------GG?????AKDAWEVF----VGFICKTLGD---YM-------------???------------------------------------KELS
myo-Dolabella2 ------------------------------------A---------------------------------------------------------------LSAAEAEVVAKSWGPVF--A-NK---DANGDNFLIALFEAYPDSPNFFA------D-F--KG----K-SIADIRASPKLRNVSSRIVSRLNEFVSSAA---D-AGKMAAMLDQ---FSKEH-AGFG---V-GSQQFQNVSAMFPGFVASI-------AAPPAG?????ADAAWGKL----FGLIIDAMKK--AGK-------------???----------------------------------------
myo-snail2 ------------------------------------S---------------------------------------------------------------LQPASKSALASSWKTLA--K-DAATIQNNGATLFSLLFKQFPDTRNYFT------H-F--GN----M-SDAEMKTTGVGKAHSMAVFAGIGSMIDSMD---D-ADCMNGLALK---LSRNH-IQRK---I-GASRFGEMRQVFPNFLDEA-----LGGGASGD?????VKGAWDAL----LAYLQDNKQA--QAL-------------???----------------------------------------
drosophila2 ----M------------------------------------------------------------------------------------------------NSDEVQLIKKTWEIPV--A-TP---TDSGAAILTQFFNRFPSNLEKFP--------F--RD----V-PLEELSGNARFRAHAGRIIRVFDESIQVLGQDGD-LEKLDEIWTK---IAVSH-IPRT---V-SKESYNQLKGVILDVLTAA-----CSLDES--?????QAATWAKLVDHVYAIIFKAIDDDG-NA-------------???----------------------------------------
midge-82 AVTPM------------------------------------------------------------------------------------------------SADQLALFKSSWNTVK--H-NE-------VDILYAVFKANPDIQAKFP------Q-F--AG----K-DLDSIKDSADFAVHSGRIVGFFSEVIGLIGNPEN-RPALKTLIDG---LASSH-KARG---I-EKAQFEEFRASLVDYLSHH-----LDWNDT--?????MKSTWDLALNNMFFYILHALEV---AQ-------------???----------------------------------------
honeybee2 ----M-GTFLRFLGISSSDDNRIDQAT---------G---------------------------------------------------------------LTERQKKLVQNTWAVVR--K-DE---VASGIAVMTAFFKKYPEYQRYFT------A-F--MD----T-PLNELPANKRFQAHCAGVITALNNVIDFLH---D-PGLMEASLIG---LVERH-KKRG---Q-TKEEFQNLKEVMLEVLRQA-----LGKQYTPE?????VAEAWNKTLDMMFGKIYQVFAS------------------???----------------------------------------
beetle2 ----M-GQLISLYKYYTTRTDDPDPLT---------T---------------------------------------------------------------LTSREVFLVQSSWDPIK--K-DL---TGYGVQLLLFLFKKYPEEQQNFP--------F--RD----M-PFEELGASKKFHAHCSNVMYAVDSIIDSLK---D-GELLVNILEK---IGRNH-HRNT---V-KPISFWHVKETMLEFFKKM-----M----NDE?????TLKAWDKALQVAFGVVAKELDK---KN-------------???----------------------------------------
cyto-beetle2 ----M-GIITSTLSYYMTKTNDPDPIT---------G---------------------------------------------------------------LTSRDRYVIQTSWAPVK--K-DL---TGNGVALLLLYFEKFPATKNYFV--------F--KD----V-PNEKLKTDKKFHAHCNSVMVTLDSLIANLN---D-GELIVSLLEK---LGKNH-KRHG---I-KDDAYDQLKETVIELFSSF-----M----TKE?????ELETWDKLLKVAFSVIIKYL--------------------???----------------------------------------
myo-human2 ----M-------------------------------G---------------------------------------------------------------LSDGEWQLVLNVWGKVE--A-DI---PGHGQEVLIRLFKGHPETLEKFD------K-F--KH----LKSEDEMKASEDLKKHGATVLTALGGILKKKG---H----HEAEIKP---LAQSHATKHK---I-PVKYLEFISECIIQVLQSK-----HPGDFGAD?????AQGAMNKA----LELFRKDMAS---NY-------------???----KELGFQG-----------------------------
myo-shark2 -------------------------------------------------------------------------------------------------------VDWEKVNSVWSAVE--S-DL---TAIGQNILLRLFEQYPESQNHFP------K-F--KN-----KSLGELKDTADIKAQADTVLSALGNIVKKKG---S----HSQPVKA---LAATHITTHK---I-PPHYFTKITTIAVDVLSEM-----YPSEMNAQ?????VQAAFSGA----FKIICSDIEK---EY-------------???----KAANFQG-----------------------------
cyto-fish2 ----M-------------------------------SHREPPPPQLAVQRRDVDGQDGPERAEP------------------------------------LSDTEREMIRDAWGHVY--K-NC---EDVGVSILIRFFVNFPSAKQYFS------Q-F--QD----MEEPEEMERSSQLRHHACRVMNALNTVVENLH---D-PEKVSSVLAV---VGRAHAVKHK---V-EPMYFKILSGVILEVLCED-----FPEFFTAD?????VQLVWSKL----MATVYWHVTG---AY-------------???-----------TDVGWLQ-----------VSSSAV-----
cyto-human2 ----M----------------------------------EKVPGEMEIERR--------ERSEE------------------------------------LSEAERKAVQAMWARLY--A-NC---EDVGVAILVRFFVNFPSAKQYFS------Q-F--KH----MEDPLEMERSPQLRKHACRVMGALNTVVENLH---D-PDKVSSVLAL---VGKAHALKHK---V-EPVYFKILSGVILEVVAEE-----FASDFPPE?????TQRAWAKL----RGLIYSHVTA---AY-------------???-----------KEVGWVQQVPNATTPPATLPSSGP-----
hagfish2 ----M-------------------------------S---------------------------------------AHGIAR------------------TTEGERAAVRASWAVLM--K-DY---EHAGVQILDKFFKANPAAKPFFT------K-M--KD----LHTLEDLASSADARWHVERIIQAVNFAVINIE---D-REKLSNKFVK---LSQDHIEEFH---VTDPQYFMILSQTILDEVEKR------NGGLSGE?????GKSGWHKV----MTIICKMLKS---KY-------------???----------------------------------------
lamprey2 ----M----------------------PIVDSGSVPA---------------------------------------------------------------LTAAEKATIRTAWAPVY--A-KY---QSTGVDILIKFFTSNPAAQAFFP------K-F--QG----LTSADQLKKSMDVRWHAERIINAVNDAVVAMD---D-TEKMSLKLRE---LSGKHAKSFQ---V-DPQYFKVLAAVIVDTV--------LPGD----?????--AGLEKL----MSMICILLRS---SY-------------???----------------------------------------
hemo-alpha-human2 ----M-------------------------------V---------------------------------------------------------------LSPADKTNVKAAWGKVG--A-HA---GEYGAEALERMFLSFPTTKTYFP------H-F---D----LSH-----GSAQVKGHGKKVADALTNAVAHVD---D----MPNALSA---LSDLHAHKLR---V-DPVNFKLLSHCLLVTLAAH-----LPAEFTPA?????VHASLDKF----LASVSTVLTS---KY-------------???-----------------------------------R----
hemo-alpha-shark2 ------------------------------------V---------------------------------------------------------------LSAADKTAIKHLTGSLR--T-NA---EAWGAESLARMFATTPSTKTYFS------K-F--TD----FSA-----NGKRVKAHGGKVLNAVADATDHLD---N----VAGHLDP---LAVLHGTTLC---V-DPHNFPLLTQCILVTLAAH-----L-TELKPE?????THCALDKF----LCEVATALGS---HY-------------???-----------------------------------R----
hemo-beta-human2 ----M-------------------------------V--------------------------------------H------------------------LTPEEKSAVTALWGKV-----NV---DEVGGEALGRLLVVYPWTQRFFE------S-F--GD----LSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLD---N----LKGTFAT---LSELHCDKLH---V-DPENFRLLGNVLVCVLAHH-----FGKEFTPP?????VQAAYQKV----VAGVANALAH---KY-------------???-----------------------------------H----
hemo-beta-shark2 ------------------------------------V--------------------------------------H------------------------WTGEEKALVNAVWTKT-----DH---QAVVAKALERLFVVYPWTKTYFV------K-F--NGK---FHASD-----STVQTHAGKVVSALTVAYNHID---D----VKPHFVE---LSKKHYEELH---V-DPENFKLLANCLEVELGHA-----LHKEFTPE?????VQAAWSKF----SNVVVDALSK---GY-------------???-----------------------------------H----