1........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370....
hemo-tunicate-1 ----M---------------------------------------------------------P--------?-----------F------------------TDEELKLLRDSWDEVK--KLGM---KEVGLHIFTGLLNAAPSLRTLF??-?--YTIDLPDEEEL?????????--?TIDVM?RENKKVVAHATRIANAISKFIKFLD??--?Q-P???-DELEKLLTS???LGESH-ARRQ---V-DPESFEYVAPVILSVIGGH?????LKLPSNSPT???????-?????LQAWVKA----YGVLRNGIVS?A??-M----------------------------------------------------EA
hemo-tunicate-3 ----M---------------------------------------------------------S--------?-----------L------------------TSEQVVLLRSSWQTIG--KLGM---SNVGLAVLHRLFNDVPETLPFF??-?--HSVLSP?TQQT????????---?EIEVL?KSNAKVVRHASRVGLSIDKIINLLD??--?N-G???-EELVKYLLF???LGQVH-VKRS---I-PRKYFSAMGPVLLSVISAV?????LEKDLDAPV???????-?????MQAWATA----YGVIEQGIID?G??-M------------------------------------------------------
hemo-polychaete-4 ----M---------------------------------------------------------G-------??-----------L------------------SAAQRQVVASTWKDIAGSD-NG---AGVGKECFTKFLSAHHDIAAVFG--F----------SGA?-?---------S-------DPGVADLGAKVLAQIGVAVSHLG??--?D-E???-GKMVAEMKA???VGVRH-KGYGYKHI-KAEYFEPLGASLLSAMEHR?????IGGKMTAAA???????-?????KDAWAAA----YADISGALIS?G???L----------------------------------------------QS------
myo-polychaete ----M-----------------------------------A---------------------G-------??-----------L------------------SGADIAVIRSTWAKVQGSG-SA---TDIGRSIFIKFFELDPAAQNEFP--C---------?KGE?????????--?SLAAL?KTNVLLGQHGAKFMEYITTAVNGLD??--?DYA???-GKAHGPLTE???LGSRH-KTRG---T-TPANFGKAGEALLAILASV?????VGGDFTPAA???????-?????KDAWTKV----YNTISSTMQA?A??-L------------------------------------------------------
leghemo-pea ----M---------------------------------------------------------G--------?-----------F------------------TEKQEALVNSSWELFK--Q-NP---SY?SVLFYTIILKKAPAAKGMFS--F----------LKD?????????--?SAE??VVDSPKLQAHAEKVFGMVHDSAIQLR??--?A-S???-GEVVLGDAT---LGAIH-IQKG---V-VDPHFVVVKEALLETIKEA?????SGEKWSEEL???????-?????STAWEVA----YEGLASAIKK?A---M------------------------------------------N-----------
leghemo-rice ----M---------------------------------------------------------A--------?LVEDNNAVAVSF------------------SEEQEALVLKSWAILK--K-DS---ANIALRFFLKIFEVAPSASQMFS--F---------?LRN?????????--?SDVPL?EKNPKLKTHAMSVFVMTCEAAAQLR??--?K-A???-GKVTVRDTTLKRLGATH-LKYG---V-GDAHFEVVKFALLDTIKEE????VPADMWSPAM???????-?????KSAWSEA----YDHLVAAIKQ?E???M------------------------------------------KPAE--------
neuro-human ----M---------------------------------------------------------E-------RP--------------------------------?EPELIRQSWRAVS--R-SP---LEHGTVLFARLFALEPDLLPLFQ--Y---------?NC?????????RQFSSPEDC?LSSPEFLDHIRKVMLVIDAAVTNVE??--?D-L???-SSLEEYLAS???LGRKH-RAVG---V-KLSSFSTVGESLLYMLEKC?????LGPAFTPAT???????-?????RAAWSQL----YGAVVQAMSR?G??-W----------------------------------?DGE----------------
neuro-zebrafish ----M---------------------------------------------------------E-------K?-----------L------------------SEKDKGLIRDSWESLG--K-NK---VPHGIVLFTRLFELDPALLTLFS--YST-------?NCG?????????--?DAPEC?LSSPEFLEHVTKVMLVIDAAVSHLD??--?D-L???-HTLEDFLLN???LGRKH-QAVG---V-NTQSFALVGESLLYMLQSS?????LGPAYTTSL???????-?????RQAWLTM----YSIVVSAMTR?G??-W--------------------------------AKN?GEHKSN------------
HbA-blood_clam ----M---------------------------------------------------------A--------?-----------?DEEQIAKAVFKEAKALCDSDAAKENLRSSFKILA--N-DI---ESSGLQLMKNLFTSHPDTLGYFAR-F--?----???KDV?????????--?SLG---KQNWQLRGHAITLMYALMNFVDALD??--?E-P???-DRLKCVVLK???FAVNH-NNRS---I-SPQVFGKINGPMDLLLKQR?????MGKYYNRET???????-?????ANAWKQL----VGVVQAALTT?P???N------------------------------------------------------
HbI-Lucina ----M---------------------------------------------------------S--------?-----------L------------------SAAQKDNVKSSWAKAS--A-AW---GTAGPEFFMALFDAHDDVFAKFSGLF--?----???KGA?????????--?AKGTV?KNTPEMAAQAQSFKGLVSNWVDNLD??--?N-A???-GALEGQCKT???FAANH-KARG---I-SAGQLEAAFKVLAGFMKSY???---?-----------------GGDEGAWTAV----AGALMGMIRP?N??-M------------------------------------------------------
HbII-Lucina ----T---------------------------------------------------------T--------?-----------L------------------TNPQKAAIRSSWSKFM--D-NG---VSNGQGFYMDLFKAHPETLTPFKSLF--?----???GGL?????????--?TLAQL?QDNPKMKAQSLVFCNGMSSFVDHLD??--?D--N??--MLVVLIQK???MAKLH-NNRG---I-RASDLRTAYDILIHYMEDH????????-----????-??NHMVGGAKDAWEVF----VGFICKTLGD?Y???M------------------------------------------------KELS--
myo-Dolabella --------------------------------------------------------------A--------?-----------L------------------SAAEAEVVAKSWGPVF--A-NK---DANGDNFLIALFEAYPDSPNFFAD-F--?----???KGK?????????--?SIADI?RASPKLRNVSSRIVSRLNEFVSSAA??--?D-A???-GKMAAMLDQ???FSKEH-AGFG---V-GSQQFQNVSAMFPGFVASI?????A????????APPAGA---????DAAWGKL----FGLIIDAMKKAG??-K------------------------------------------------------
myo-snail --------------------------------------------------------------S--------?-----------L------------------QPASKSALASSWKTLA--K-DAATIQNNGATLFSLLFKQFPDTRNYFTH-F--?----???GNM?????????--?SDAEM?KTTGVGKAHSMAVFAGIGSMIDSMD??--?D-A???-DCMNGLALK???LSRNH-IQRK---I-GASRFGEMRQVFPNFLDEA?????LGGGASGDV???????-?????KGAWDAL----LAYLQDNKQAQA??-L------------------------------------------------------
drosophila ----M------------------------------------------------------------------?------------------------------NSDEVQLIKKTWEIPV--A-TP---TDSGAAILTQFFNRFPSNLEKFP--F----------RDV?????????--?PLEEL?SGNARFRAHAGRIIRVFDESIQVLG??QDGD-L????EKLDEIWTK???IAVSH-IPRT---V-SKESYNQLKGVILDVLTAA?????CSLDES??Q??????---????AATWAKLVDHVYAIIFKAIDD??DGNA------------------------------------------------------
midge-8 AVTPM------------------------------------------------------------------?------------------------------SADQLALFKSSWNTVK--H-NE-------VDILYAVFKANPDIQAKFPQ-F--?----???AGK?????????--?DLDSI?KDSADFAVHSGRIVGFFSEVIGLIG?????N-P?ENRPALKTLIDG???LASSH-KARG---I-EKAQFEEFRASLVDYLSHH?????LDWNDT??M??????---????KSTWDLALNNMFFYILHALEV?A???Q------------------------------------------------------
honeybee ----M------------------------------------GTFLRFLGISSSDDNRIDQATG--------?-----------L------------------TERQKKLVQNTWAVVR--K-DE---VASGIAVMTAFFKKYPEYQRYFTA-F--?----???MDT?????????--?PLNEL?PANKRFQAHCAGVITALNNVIDFLH??--?D-P???-GLMEASLIG???LVERH-KKRG---Q-TKEEFQNLKEVMLEVLRQA?????LGKQYTPEV???????-?????AEAWNKTLDMMFGKIYQVFAS------------------------------------------------------------
beetle ----M------------------------------------GQLISLYKYYTTRTDDPDPLTT--------?-----------L------------------TSREVFLVQSSWDPIK--K-DL---TGYGVQLLLFLFKKYPEEQQNFP--F----------RDM?????????--?PFEEL?GASKKFHAHCSNVMYAVDSIIDSLK??--?D-G???-ELLVNILEK???IGRNH-HRNT---V-KPISFWHVKETMLEFFKKM???-?M----NDET----??----???LKAWDKALQVAFGVVAKELDK?K??-N------------------------------------------------------
cyto-beetle ----M------------------------------------GIITSTLSYYMTKTNDPDPITG--------?-----------L------------------TSRDRYVIQTSWAPVK--K-DL---TGNGVALLLLYFEKFPATKNYFV--F----------KDV?????????--?PNEKL?KTDKKFHAHCNSVMVTLDSLIANLN??--?D-G???-ELIVSLLEK???LGKNH-KRHG---I-KDDAYDQLKETVIELFSSF???-?M----TKEE----??----???LETWDKLLKVAFSVIIKYL--------------------------------------------------------------
myo-human ----M---------------------------------------------------------G--------?-----------L------------------SDGEWQLVLNVWGKVE--A-DI---PGHGQEVLIRLFKGHPETLEKFDK-F--?----???KHLK????????--?SEDEM?KASEDLKKHGATVLTALGGILKKK-GH------------HEAEIKP???LAQSHATKHK---I-PVKYLEFISECIIQVLQSK?????HPGDFGADA???????-?????QGAMNKA----LELFRKDMAS?N???Y------------------------KELGFQG-----------------------
myo-shark --------------------------------------------------------------------------------------------------------VDWEKVNSVWSAVE--S-DL---TAIGQNILLRLFEQYPESQNHFPK-F--?----???KN-K???????----SLGEL?KDTADIKAQADTVLSALGNIVKKK-GS------------HSQPVKA???LAATHITTHK---I-PPHYFTKITTIAVDVLSEM?????YPSEMNAQV???????-?????QAAFSGA----FKIICSDIEK?E???Y------------------------KAANFQG-----------------------
cyto-fish ----MSHREPPPPQLAVQRRDVDGQDGPERAEP?----------------------------?--------?-----------L------------------SDTEREMIRDAWGHVY--K-NC---EDVGVSILIRFFVNFPSAKQYFSQ-F--?----???QDME????????--?EPEEM?ERSSQLRHHACRVMNALNTVVENLH??--?D-P???-EKVSSVLAV???VGRAHAVKHK---V-EPMYFKILSGVILEVLCED?????FPEFFTADV???????-?????QLVWSKL----MATVYWHVTG?A???YTDVGWLQ-----------VSSSAV------------------------------
cyto-human ----M---EKVPGEMEIERR--------ERSEE--------------------------------------?-----------L------------------SEAERKAVQAMWARLY--A-NC---EDVGVAILVRFFVNFPSAKQYFSQ-F--?----???KHME????????--?DPLEM?ERSPQLRKHACRVMGALNTVVENLH??--?D-P???-DKVSSVLAL???VGKAHALKHK---V-EPVYFKILSGVILEVVAEE?????FASDFPPET???????-?????QRAWAKL----RGLIYSHVTA?A???YKEVGWVQQVPNATTPPATLPSSGP------------------------------
hagfish ----M----------------------------?-----?----------------------S-AHGIAR-?-----------T------------------TEGERAAVRASWAVLM--K-DY---EHAGVQILDKFFKANPAAKPFFTK-M--?----???KDLH????????--?TLEDL?ASSADARWHVERIIQAVNFAVINIE??--?D-R???-EKLSNKFVK???LSQDHIEEFH---VTDPQYFMILSQTILDEV???EKRN???GGLSGEG??????---????KSGWHKV----MTIICKMLKS?K??-Y------------------------------------------------------
lamprey ----M---------------------------?PIVDSGS----------------------?-???VPA-?-----------L------------------TAAEKATIRTAWAPVY--A-KY---QSTGVDILIKFFTSNPAAQAFFPK-F--?----???QGLT????????--?SADQL?KKSMDVRWHAERIINAVNDAVVAMD??--?D-T???-EKMSLKLRE???LSGKHAKSFQ---V-DPQYFKVLAAVIVDTV-----??-LPGD-----?-------------AGLEKL----MSMICILLRS?S??-Y------------------------------------------------------
hemo-alpha-human ----M---------------------------------------------------------V--------?-----------L------------------SPADKTNVKAAWGKVG--A-HA---GEYGAEALERMFLSFPTTKTYFPH-F--?--------DLSH???--------------GSAQVKGHGKKVADALTNAVAHVD??--?D--------MPNALSA???LSDLHAHKLR---V-DPVNFKLLSHCLLVTLAAH?????LPAEFTPAV???????-?????HASLDKF----LASVSTVLTS?K??-Y-------------------------------R----------------------
hemo-alpha-shark --------------------------------------------------------------V--------?-----------L------------------SAADKTAIKHLTGSLR--T-NA---EAWGAESLARMFATTPSTKTYFSK-F--?-------TDFSA???---?--??------NGKRVKAHGGKVLNAVADATDHLD??--?N--------VAGHLDP???LAVLHGTTLC---V-DPHNFPLLTQCILVTLAAH?????L-TELKPET??????--?????HCALDKF----LCEVATALGS?H??-Y-------------------------------R----------------------
hemo-beta-human ----M---------------------------------------------------------VH-------?-----------L------------------TPEEKSAVTALWGKV-----NV---DEVGGEALGRLLVVYPWTQRFFES-F--?----???GDLS????????--?TPDAV?MGNPKVKAHGKKVLGAFSDGLAHLD??--?N--------LKGTFAT???LSELHCDKLH---V-DPENFRLLGNVLVCVLAHH?????FGKEFTPPV???????-?????QAAYQKV----VAGVANALAH?K??-Y-------------------------------H----------------------
hemo-beta-shark --------------------------------------------------------------VH-------?-----------W------------------TGEEKALVNAVWTKT-----DH---QAVVAKALERLFVVYPWTKTYFVK-F--?-----??NG???KFHASD----??-------STVQTHAGKVVSALTVAYNHID??--?D--------VKPHFVE???LSKKHYEELH---V-DPENFKLLANCLEVELGHA?????LHKEFTPEV???????-?????QAAWSKF----SNVVVDALSK?G??-Y-------------------------------H----------------------