1........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360......
hemo-tunicate-1 ----M---------------------------------------------------------P--------?-----------F------------------TDEELKLLRDSWDEVK--KLGM---KEVGLHIFTGLLNAAPSLRTLF---?--YTIDLPDEEEL-?----??----TIDVMRENKKVVAHATRIANAISKFIKFLD??---Q-P??--DELEKLLTS---LGESH-ARRQ---V-DPESFEYVAPVILSVIGGH??LKLP??SNSPT----???LQAWVKA----YGVLRNGIVS?A---M----------------------------------------------------EA
hemo-tunicate-3 ----M---------------------------------------------------------S--------?-----------L------------------TSEQVVLLRSSWQTIG--KLGM---SNVGLAVLHRLFNDVPETLPFF---?--HSVLSP?TQQT-?----??----EIEVLKSNAKVVRHASRVGLSIDKIINLLD??---N-G??--EELVKYLLF---LGQVH-VKRS---I-PRKYFSAMGPVLLSVISAV??LEKD??LDAPV----???MQAWATA----YGVIEQGIID?G---M------------------------------------------------------
hemo-polychaete-4 ----M---------------------------------------------------------G--------?-----------L------------------SAAQRQVVASTWKDIAGSD-NG---AGVGKECFTKFLSAHHDIAAVFG--F----------SGA------------S------DPGVADLGAKVLAQIGVAVSHLG??---D-E??--GKMVAEMKA---VGVRH-KGYGYKHI-KAEYFEPLGASLLSAMEHR??IGGK??MTAAA----???KDAWAAA----YADISGALIS?G---L----------------------------------------------QS------
myo-polychaete ----M-----------------------------------A---------------------G--------?-----------L------------------SGADIAVIRSTWAKVQGSG-SA---TDIGRSIFIKFFELDPAAQNEFP--C----------KGE-?----??----SLAALKTNVLLGQHGAKFMEYITTAVNGLD??---DYA??--GKAHGPLTE---LGSRH-KTRG---T-TPANFGKAGEALLAILASV??VGGD??FTPAA----???KDAWTKV----YNTISSTMQA?A---L------------------------------------------------------
leghemo-pea ----M---------------------------------------------------------G--------?-----------F------------------TEKQEALVNSSWELFK--Q-NP---SY-SVLFYTIILKKAPAAKGMFS--F----------LKD-------?----SAEV?VDSPKLQAHAEKVFGMVHDSAIQLR??---A-S??--GEVVLGDAT---LGAIH-IQKG---V-VDPHFVVVKEALLETIKEA??SGEK??WSEEL----???STAWEVA----YEGLASAIKK-A---M------------------------------------------N-----------
leghemo-rice ----M---------------------------------------------------------A--------?LVEDNNAVAVSF------------------SEEQEALVLKSWAILK--K-DS---ANIALRFFLKIFEVAPSASQMFS--F----------LRN-?----??----SDVPLEKNPKLKTHAMSVFVMTCEAAAQLR??---K-A??--GKVTVRDTTLKRLGATH-LKYG---V-GDAHFEVVKFALLDTIKEE?VPADM??WSPAM----???KSAWSEA----YDHLVAAIKQ?E---M------------------------------------------KPAE--------
neuro-human ----M---------------------------------------------------------E-------RP---------------------------------EPELIRQSWRAVS--R-SP---LEHGTVLFARLFALEPDLLPLFQ--Y----------NC--?----??RQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVE??---D-L??--SSLEEYLAS---LGRKH-RAVG---V-KLSSFSTVGESLLYMLEKC??LGPA??FTPAT----???RAAWSQL----YGAVVQAMSR-G---W-----------------------------------DGE----------------
neuro-zebrafish ----M---------------------------------------------------------E-------K?-----------L------------------SEKDKGLIRDSWESLG--K-NK---VPHGIVLFTRLFELDPALLTLFS--YST--------NCG-?----??----DAPECLSSPEFLEHVTKVMLVIDAAVSHLD??---D-L??--HTLEDFLLN---LGRKH-QAVG---V-NTQSFALVGESLLYMLQSS??LGPA??YTTSL----???RQAWLTM----YSIVVSAMTR?G---W--------------------------------AKN?GEHKSN------------
HbA-blood_clam ----M---------------------------------------------------------A--------?------------DEEQIAKAVFKEAKALCDSDAAKENLRSSFKILA--N-DI---ESSGLQLMKNLFTSHPDTLGYFAR-F----------KDV------??----SLG--KQNWQLRGHAITLMYALMNFVDALD??---E-P??--DRLKCVVLK---FAVNH-NNRS---I-SPQVFGKINGPMDLLLKQR??MGKY??YNRET----???ANAWKQL----VGVVQAALTT?P---N------------------------------------------------------
HbI-Lucina ----M---------------------------------------------------------S--------?-----------L------------------SAAQKDNVKSSWAKAS--A-AW---GTAGPEFFMALFDAHDDVFAKFSGLF----------KGA-?----??----AKGTVKNTPEMAAQAQSFKGLVSNWVDNLD??---N-A??--GALEGQCKT---FAANH-KARG---I-SAGQLEAAFKVLAGFMKSY-----------------GGDEGAWTAV----AGALMGMIRP?N---M------------------------------------------------------
HbII-Lucina ----T---------------------------------------------------------T--------?-----------L------------------TNPQKAAIRSSWSKFM--D-NG---VSNGQGFYMDLFKAHPETLTPFKSLF----------GGL-?----??----TLAQLQDNPKMKAQSLVFCNGMSSFVDHLD-?---D--N----MLVVLIQK---MAKLH-NNRG---I-RASDLRTAYDILIHYMEDH-------------NHMVGGAKDAWEVF----VGFICKTLGD?Y---M------------------------------------------------KELS--
myo-Dolabella --------------------------------------------------------------A--------?-----------L------------------SAAEAEVVAKSWGPVF--A-NK---DANGDNFLIALFEAYPDSPNFFAD-F----------KGK-?----??----SIADIRASPKLRNVSSRIVSRLNEFVSSAA??---D-A??--GKMAAMLDQ---FSKEH-AGFG---V-GSQQFQNVSAMFPGFVASI--AA--PPA--GA-----??DAAWGKL----FGLIIDAMKKAG---K------------------------------------------------------
myo-snail --------------------------------------------------------------S--------?-----------L------------------QPASKSALASSWKTLA--K-DAATIQNNGATLFSLLFKQFPDTRNYFTH-F----------GNM-?----??----SDAEMKTTGVGKAHSMAVFAGIGSMIDSMD??---D-A??--DCMNGLALK---LSRNH-IQRK---I-GASRFGEMRQVFPNFLDEA??LGGG??ASGDV----???KGAWDAL----LAYLQDNKQAQA---L------------------------------------------------------
drosophila ----M-------------------------------------------------------------------------------------------------NSDEVQLIKKTWEIPV--A-TP---TDSGAAILTQFFNRFPSNLEKFP--F----------RDV-?----??----PLEELSGNARFRAHAGRIIRVFDESIQVLG??QDGD-L???-EKLDEIWTK---IAVSH-IPRT---V-SKESYNQLKGVILDVLTAA??CSLD-?ES--Q-------AATWAKLVDHVYAIIFKAIDD?-DGNA------------------------------------------------------
midge-8 AVTPM-------------------------------------------------------------------------------------------------SADQLALFKSSWNTVK--H-NE-------VDILYAVFKANPDIQAKFPQ-F----------AGK-?----??----DLDSIKDSADFAVHSGRIVGFFSEVIGLIG??--?N-P?ENRPALKTLIDG---LASSH-KARG---I-EKAQFEEFRASLVDYLSHH??LDWN-?DT--M------?KSTWDLALNNMFFYILHALEV?A---Q------------------------------------------------------
honeybee ----M------------------------------------GTFLRFLGISSSDDNRIDQATG--------?-----------L------------------TERQKKLVQNTWAVVR--K-DE---VASGIAVMTAFFKKYPEYQRYFTA-F----------MDT-?----??----PLNELPANKRFQAHCAGVITALNNVIDFLH??---D-P??--GLMEASLIG---LVERH-KKRG---Q-TKEEFQNLKEVMLEVLRQA??LGKQ??YTPEV----???AEAWNKTLDMMFGKIYQVFAS------------------------------------------------------------
beetle ----M------------------------------------GQLISLYKYYTTRTDDPDPLTT--------?-----------L------------------TSREVFLVQSSWDPIK--K-DL---TGYGVQLLLFLFKKYPEEQQNFP--F----------RDM-?----??----PFEELGASKKFHAHCSNVMYAVDSIIDSLK??---D-G??--ELLVNILEK---IGRNH-HRNT---V-KPISFWHVKETMLEFFKKM--M------NDET-------LKAWDKALQVAFGVVAKELDK?K---N------------------------------------------------------
cyto-beetle ----M------------------------------------GIITSTLSYYMTKTNDPDPITG--------?-----------L------------------TSRDRYVIQTSWAPVK--K-DL---TGNGVALLLLYFEKFPATKNYFV--F----------KDV-?----??----PNEKLKTDKKFHAHCNSVMVTLDSLIANLN??---D-G??--ELIVSLLEK---LGKNH-KRHG---I-KDDAYDQLKETVIELFSSF--M------TKEE-------LETWDKLLKVAFSVIIKYL--------------------------------------------------------------
myo-human ----M---------------------------------------------------------G--------?-----------L------------------SDGEWQLVLNVWGKVE--A-DI---PGHGQEVLIRLFKGHPETLEKFDK-F----------KHLK?-?????----SEDEMKASEDLKKHGATVLTALGGILKKK-GH------------HEAEIKP---LAQSHATKHK---I-PVKYLEFISECIIQVLQSK??HPGD??FGADA----???QGAMNKA----LELFRKDMAS?N---Y------------------------KELGFQG-----------------------
myo-shark --------------------------------------------------------------------------------------------------------VDWEKVNSVWSAVE--S-DL---TAIGQNILLRLFEQYPESQNHFPK-F----------KN-K?---???----SLGELKDTADIKAQADTVLSALGNIVKKK-GS------------HSQPVKA---LAATHITTHK---I-PPHYFTKITTIAVDVLSEM??YPSE??MNAQV----???QAAFSGA----FKIICSDIEK?E---Y------------------------KAANFQG-----------------------
cyto-fish ----MSHREPPPPQLAVQRRDVDGQDGPERAEP--------------------------------------?-----------L------------------SDTEREMIRDAWGHVY--K-NC---EDVGVSILIRFFVNFPSAKQYFSQ-F----------QDME?-?????----EPEEMERSSQLRHHACRVMNALNTVVENLH??---D-P??--EKVSSVLAV---VGRAHAVKHK---V-EPMYFKILSGVILEVLCED??FPEF??FTADV----???QLVWSKL----MATVYWHVTG?A---YTDVGWLQ-----------VSSSAV------------------------------
cyto-human ----M---EKVPGEMEIERR--------ERSEE--------------------------------------?-----------L------------------SEAERKAVQAMWARLY--A-NC---EDVGVAILVRFFVNFPSAKQYFSQ-F----------KHME?-?????----DPLEMERSPQLRKHACRVMGALNTVVENLH??---D-P??--DKVSSVLAL---VGKAHALKHK---V-EPVYFKILSGVILEVVAEE??FASD??FPPET----???QRAWAKL----RGLIYSHVTA?A---YKEVGWVQQVPNATTPPATLPSSGP------------------------------
hagfish ----M---------------------------------------------------------S-AHGIAR-?-----------T------------------TEGERAAVRASWAVLM--K-DY---EHAGVQILDKFFKANPAAKPFFTK-M----------KDLH?-?????----TLEDLASSADARWHVERIIQAVNFAVINIE??---D-R??--EKLSNKFVK---LSQDHIEEFH---VTDPQYFMILSQTILDEVEK-R--NGG??LSGEG-----??KSGWHKV----MTIICKMLKS?K---Y------------------------------------------------------
lamprey ----M----------------------------PIVDSGS---------------------------VPA-?-----------L------------------TAAEKATIRTAWAPVY--A-KY---QSTGVDILIKFFTSNPAAQAFFPK-F----------QGLT?-?????----SADQLKKSMDVRWHAERIINAVNDAVVAMD??---D-T??--EKMSLKLRE---LSGKHAKSFQ---V-DPQYFKVLAAVIVDTV-----LPGD---------------AGLEKL----MSMICILLRS?S---Y------------------------------------------------------
hemo-alpha-human ----M---------------------------------------------------------V--------?-----------L------------------SPADKTNVKAAWGKVG--A-HA---GEYGAEALERMFLSFPTTKTYFPH-F-----------DLSH----------------GSAQVKGHGKKVADALTNAVAHVD-----D--------MPNALSA---LSDLHAHKLR---V-DPVNFKLLSHCLLVTLAAH??LPAE??FTPAV----???HASLDKF----LASVSTVLTS?K---Y-------------------------------R----------------------
hemo-alpha-shark --------------------------------------------------------------V--------?-----------L------------------SAADKTAIKHLTGSLR--T-NA---EAWGAESLARMFATTPSTKTYFSK-F----------TDFSA----------------NGKRVKAHGGKVLNAVADATDHLD-----N--------VAGHLDP---LAVLHGTTLC---V-DPHNFPLLTQCILVTLAAH??L-TE-?LKPET------?HCALDKF----LCEVATALGS?H---Y-------------------------------R----------------------
hemo-beta-human ----M---------------------------------------------------------VH-------?-----------L------------------TPEEKSAVTALWGKV-----NV---DEVGGEALGRLLVVYPWTQRFFES-F----------GDLS?-?????----TPDAVMGNPKVKAHGKKVLGAFSDGLAHLD-----N--------LKGTFAT---LSELHCDKLH---V-DPENFRLLGNVLVCVLAHH??FGKE??FTPPV----???QAAYQKV----VAGVANALAH?K---Y-------------------------------H----------------------
hemo-beta-shark --------------------------------------------------------------VH-------?-----------W------------------TGEEKALVNAVWTKT-----DH---QAVVAKALERLFVVYPWTKTYFVK-F----------NG---KFHASD------------STVQTHAGKVVSALTVAYNHID-----D--------VKPHFVE---LSKKHYEELH---V-DPENFKLLANCLEVELGHA??LHKE??FTPEV----???QAAWSKF----SNVVVDALSK?G---Y-------------------------------H----------------------