1........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360......
hemo-tunicate-1 ----M---------------------------------------------------------P--------?-----------F------------------TDEELKLLRDSWDEVK--KLGM---KEVGLHIFTGLLNAAPSLRTLF------YTIDLPDEEEL------------TIDVMRENKKVVAHATRIANAISKFIKFLD-----Q-P?---DELEKLLTS---LGESH-ARRQ---V-DPESFEYVAPVILSVIGGH--LKLP--SNSPT-----??LQAWVKA----YGVLRNGIVS-A---M----------------------------------------------------EA
hemo-tunicate-3 ----M---------------------------------------------------------S--------?-----------L------------------TSEQVVLLRSSWQTIG--KLGM---SNVGLAVLHRLFNDVPETLPFF------HSVLSP-TQQT------------EIEVLKSNAKVVRHASRVGLSIDKIINLLD-----N-G?---EELVKYLLF---LGQVH-VKRS---I-PRKYFSAMGPVLLSVISAV--LEKD--LDAPV-----??MQAWATA----YGVIEQGIID-G---M------------------------------------------------------
hemo-polychaete-4 ----M---------------------------------------------------------G--------?-----------L------------------SAAQRQVVASTWKDIAGSD-NG---AGVGKECFTKFLSAHHDIAAVFG--F----------SGA------------S------DPGVADLGAKVLAQIGVAVSHLG-----D-E?---GKMVAEMKA---VGVRH-KGYGYKHI-KAEYFEPLGASLLSAMEHR--IGGK--MTAAA-----??KDAWAAA----YADISGALIS-G---L----------------------------------------------QS------
myo-polychaete ----M-----------------------------------A---------------------G--------?-----------L------------------SGADIAVIRSTWAKVQGSG-SA---TDIGRSIFIKFFELDPAAQNEFP--C----------KGE------------SLAALKTNVLLGQHGAKFMEYITTAVNGLD-----DYA?---GKAHGPLTE---LGSRH-KTRG---T-TPANFGKAGEALLAILASV--VGGD--FTPAA-----??KDAWTKV----YNTISSTMQA-A---L------------------------------------------------------
leghemo-pea ----M---------------------------------------------------------G--------?-----------F------------------TEKQEALVNSSWELFK--Q-NP---SY-SVLFYTIILKKAPAAKGMFS--F----------LKD------------SAEV-VDSPKLQAHAEKVFGMVHDSAIQLR-----A-S?---GEVVLGDAT---LGAIH-IQKG---V-VDPHFVVVKEALLETIKEA--SGEK--WSEEL-----??STAWEVA----YEGLASAIKK-A---M------------------------------------------N-----------
leghemo-rice ----M---------------------------------------------------------A--------?LVEDNNAVAVSF------------------SEEQEALVLKSWAILK--K-DS---ANIALRFFLKIFEVAPSASQMFS--F----------LRN------------SDVPLEKNPKLKTHAMSVFVMTCEAAAQLR-----K-A?---GKVTVRDTTLKRLGATH-LKYG---V-GDAHFEVVKFALLDTIKEE-VPADM--WSPAM-----??KSAWSEA----YDHLVAAIKQ-E---M------------------------------------------KPAE--------
neuro-human ----M---------------------------------------------------------E-------RP---------------------------------EPELIRQSWRAVS--R-SP---LEHGTVLFARLFALEPDLLPLFQ--Y----------NC---------RQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVE-----D-L?---SSLEEYLAS---LGRKH-RAVG---V-KLSSFSTVGESLLYMLEKC--LGPA--FTPAT-----??RAAWSQL----YGAVVQAMSR-G---W-----------------------------------DGE----------------
neuro-zebrafish ----M---------------------------------------------------------E-------K?-----------L------------------SEKDKGLIRDSWESLG--K-NK---VPHGIVLFTRLFELDPALLTLFS--YST--------NCG------------DAPECLSSPEFLEHVTKVMLVIDAAVSHLD-----D-L?---HTLEDFLLN---LGRKH-QAVG---V-NTQSFALVGESLLYMLQSS--LGPA--YTTSL-----??RQAWLTM----YSIVVSAMTR-G---W--------------------------------AKN-GEHKSN------------
HbA-blood_clam ----M---------------------------------------------------------A--------?------------DEEQIAKAVFKEAKALCDSDAAKENLRSSFKILA--N-DI---ESSGLQLMKNLFTSHPDTLGYFAR-F----------KDV------------SLG--KQNWQLRGHAITLMYALMNFVDALD-----E-P?---DRLKCVVLK---FAVNH-NNRS---I-SPQVFGKINGPMDLLLKQR--MGKY--YNRET-----??ANAWKQL----VGVVQAALTT-P---N------------------------------------------------------
HbI-Lucina ----M---------------------------------------------------------S--------?-----------L------------------SAAQKDNVKSSWAKAS--A-AW---GTAGPEFFMALFDAHDDVFAKFSGLF----------KGA------------AKGTVKNTPEMAAQAQSFKGLVSNWVDNLD-----N-A?---GALEGQCKT---FAANH-KARG---I-SAGQLEAAFKVLAGFMKSY-----------------GGDEGAWTAV----AGALMGMIRP-N---M------------------------------------------------------
HbII-Lucina ----T---------------------------------------------------------T--------?-----------L------------------TNPQKAAIRSSWSKFM--D-NG---VSNGQGFYMDLFKAHPETLTPFKSLF----------GGL------------TLAQLQDNPKMKAQSLVFCNGMSSFVDHLD-----D--N----MLVVLIQK---MAKLH-NNRG---I-RASDLRTAYDILIHYMEDH-------------NHMVGGAKDAWEVF----VGFICKTLGD-Y---M------------------------------------------------KELS--
myo-Dolabella --------------------------------------------------------------A--------?-----------L------------------SAAEAEVVAKSWGPVF--A-NK---DANGDNFLIALFEAYPDSPNFFAD-F----------KGK------------SIADIRASPKLRNVSSRIVSRLNEFVSSAA-----D-A?---GKMAAMLDQ---FSKEH-AGFG---V-GSQQFQNVSAMFPGFVASI--AA--PPA--GA-------DAAWGKL----FGLIIDAMKKAG---K------------------------------------------------------
myo-snail --------------------------------------------------------------S--------?-----------L------------------QPASKSALASSWKTLA--K-DAATIQNNGATLFSLLFKQFPDTRNYFTH-F----------GNM------------SDAEMKTTGVGKAHSMAVFAGIGSMIDSMD-----D-A?---DCMNGLALK---LSRNH-IQRK---I-GASRFGEMRQVFPNFLDEA--LGGG--ASGDV-----??KGAWDAL----LAYLQDNKQAQA---L------------------------------------------------------
drosophila ----M-------------------------------------------------------------------------------------------------NSDEVQLIKKTWEIPV--A-TP---TDSGAAILTQFFNRFPSNLEKFP--F----------RDV------------PLEELSGNARFRAHAGRIIRVFDESIQVLG--QDGD-L??--EKLDEIWTK---IAVSH-IPRT---V-SKESYNQLKGVILDVLTAA--CSLD--ES--Q-------AATWAKLVDHVYAIIFKAIDD--DGNA------------------------------------------------------
midge-8 AVTPM-------------------------------------------------------------------------------------------------SADQLALFKSSWNTVK--H-NE-------VDILYAVFKANPDIQAKFPQ-F----------AGK------------DLDSIKDSADFAVHSGRIVGFFSEVIGLIG-----N-P?ENRPALKTLIDG---LASSH-KARG---I-EKAQFEEFRASLVDYLSHH--LDWN--DT--M-------KSTWDLALNNMFFYILHALEV-A---Q------------------------------------------------------
honeybee ----M------------------------------------GTFLRFLGISSSDDNRIDQATG--------?-----------L------------------TERQKKLVQNTWAVVR--K-DE---VASGIAVMTAFFKKYPEYQRYFTA-F----------MDT------------PLNELPANKRFQAHCAGVITALNNVIDFLH-----D-P?---GLMEASLIG---LVERH-KKRG---Q-TKEEFQNLKEVMLEVLRQA--LGKQ--YTPEV-----??AEAWNKTLDMMFGKIYQVFAS------------------------------------------------------------
beetle ----M------------------------------------GQLISLYKYYTTRTDDPDPLTT--------?-----------L------------------TSREVFLVQSSWDPIK--K-DL---TGYGVQLLLFLFKKYPEEQQNFP--F----------RDM------------PFEELGASKKFHAHCSNVMYAVDSIIDSLK-----D-G?---ELLVNILEK---IGRNH-HRNT---V-KPISFWHVKETMLEFFKKM--M------NDET-------LKAWDKALQVAFGVVAKELDK-K---N------------------------------------------------------
cyto-beetle ----M------------------------------------GIITSTLSYYMTKTNDPDPITG--------?-----------L------------------TSRDRYVIQTSWAPVK--K-DL---TGNGVALLLLYFEKFPATKNYFV--F----------KDV------------PNEKLKTDKKFHAHCNSVMVTLDSLIANLN-----D-G?---ELIVSLLEK---LGKNH-KRHG---I-KDDAYDQLKETVIELFSSF--M------TKEE-------LETWDKLLKVAFSVIIKYL--------------------------------------------------------------
myo-human ----M---------------------------------------------------------G--------?-----------L------------------SDGEWQLVLNVWGKVE--A-DI---PGHGQEVLIRLFKGHPETLEKFDK-F----------KHLK?-----?----SEDEMKASEDLKKHGATVLTALGGILKKK-GH------------HEAEIKP---LAQSHATKHK---I-PVKYLEFISECIIQVLQSK--HPGD--FGADA-----??QGAMNKA----LELFRKDMAS-N---Y------------------------KELGFQG-----------------------
myo-shark --------------------------------------------------------------------------------------------------------VDWEKVNSVWSAVE--S-DL---TAIGQNILLRLFEQYPESQNHFPK-F----------KN-K?----------SLGELKDTADIKAQADTVLSALGNIVKKK-GS------------HSQPVKA---LAATHITTHK---I-PPHYFTKITTIAVDVLSEM--YPSE--MNAQV-----??QAAFSGA----FKIICSDIEK-E---Y------------------------KAANFQG-----------------------
cyto-fish ----MSHREPPPPQLAVQRRDVDGQDGPERAEP--------------------------------------?-----------L------------------SDTEREMIRDAWGHVY--K-NC---EDVGVSILIRFFVNFPSAKQYFSQ-F----------QDME?-----?----EPEEMERSSQLRHHACRVMNALNTVVENLH-----D-P?---EKVSSVLAV---VGRAHAVKHK---V-EPMYFKILSGVILEVLCED--FPEF--FTADV-----??QLVWSKL----MATVYWHVTG-A---YTDVGWLQ-----------VSSSAV------------------------------
cyto-human ----M---EKVPGEMEIERR--------ERSEE--------------------------------------?-----------L------------------SEAERKAVQAMWARLY--A-NC---EDVGVAILVRFFVNFPSAKQYFSQ-F----------KHME?-----?----DPLEMERSPQLRKHACRVMGALNTVVENLH-----D-P?---DKVSSVLAL---VGKAHALKHK---V-EPVYFKILSGVILEVVAEE--FASD--FPPET-----??QRAWAKL----RGLIYSHVTA-A---YKEVGWVQQVPNATTPPATLPSSGP------------------------------
hagfish ----M---------------------------------------------------------S-AHGIAR-?-----------T------------------TEGERAAVRASWAVLM--K-DY---EHAGVQILDKFFKANPAAKPFFTK-M----------KDLH?-----?----TLEDLASSADARWHVERIIQAVNFAVINIE-----D-R?---EKLSNKFVK---LSQDHIEEFH---VTDPQYFMILSQTILDEVEK-R--NGG--LSGEG-------KSGWHKV----MTIICKMLKS-K---Y------------------------------------------------------
lamprey ----M----------------------------PIVDSGS---------------------------VPA-?-----------L------------------TAAEKATIRTAWAPVY--A-KY---QSTGVDILIKFFTSNPAAQAFFPK-F----------QGLT?-----?----SADQLKKSMDVRWHAERIINAVNDAVVAMD-----D-T?---EKMSLKLRE---LSGKHAKSFQ---V-DPQYFKVLAAVIVDTV-----LPGD---------------AGLEKL----MSMICILLRS-S---Y------------------------------------------------------
hemo-alpha-human ----M---------------------------------------------------------V--------?-----------L------------------SPADKTNVKAAWGKVG--A-HA---GEYGAEALERMFLSFPTTKTYFPH-F-----------DLSH----------------GSAQVKGHGKKVADALTNAVAHVD-----D--------MPNALSA---LSDLHAHKLR---V-DPVNFKLLSHCLLVTLAAH--LPAE--FTPAV-----??HASLDKF----LASVSTVLTS-K---Y-------------------------------R----------------------
hemo-alpha-shark --------------------------------------------------------------V--------?-----------L------------------SAADKTAIKHLTGSLR--T-NA---EAWGAESLARMFATTPSTKTYFSK-F----------TDFSA----------------NGKRVKAHGGKVLNAVADATDHLD-----N--------VAGHLDP---LAVLHGTTLC---V-DPHNFPLLTQCILVTLAAH--L-TE--LKPET-------HCALDKF----LCEVATALGS-H---Y-------------------------------R----------------------
hemo-beta-human ----M---------------------------------------------------------VH-------?-----------L------------------TPEEKSAVTALWGKV-----NV---DEVGGEALGRLLVVYPWTQRFFES-F----------GDLS?-----?----TPDAVMGNPKVKAHGKKVLGAFSDGLAHLD-----N--------LKGTFAT---LSELHCDKLH---V-DPENFRLLGNVLVCVLAHH--FGKE--FTPPV-----??QAAYQKV----VAGVANALAH-K---Y-------------------------------H----------------------
hemo-beta-shark --------------------------------------------------------------VH-------?-----------W------------------TGEEKALVNAVWTKT-----DH---QAVVAKALERLFVVYPWTKTYFVK-F----------NG---KFHASD------------STVQTHAGKVVSALTVAYNHID-----D--------VKPHFVE---LSKKHYEELH---V-DPENFKLLANCLEVELGHA--LHKE--FTPEV-----??QAAWSKF----SNVVVDALSK-G---Y-------------------------------H----------------------