1........10........20........30........40........50........60........70........80........90.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350..
hemo-tunicate-1 ----M--------------------------------------------------P---------------------------------------------FTDEELKLLRDSWDEVK--KLGM---KEVGLHIFTGLLNAAPSLRTLFY--TIDLPDE--EE----L-TIDVMREN--KKVVAHATRIANAISKFIKFLD------Q-P---DELEKLLTS---LGESH-ARRQ---V-DPESFEYVAPVILSVIG-GH----L-KLPSNSPTLQAWVKA----YGVLRNGIV-SA--M---------------------------------------------------EA
hemo-tunicate-3 ----M--------------------------------------------------S---------------------------------------------LTSEQVVLLRSSWQTIG--KLGM---SNVGLAVLHRLFNDVPETLPFFH--SVLSP-T--QQ----T-EIEVLKSN--AKVVRHASRVGLSIDKIINLLD------N-G---EELVKYLLF---LGQVH-VKRS---I-PRKYFSAMGPVLLSVIS-AV----L-EKDLDAPVMQAWATA----YGVIEQGII-DG--M-----------------------------------------------------
hemo-polychaete-4 ----M--------------------------------------------------G---------------------------------------------LSAAQRQVVASTWKDIAGSD-NG---AGVGKECFTKFLSAHHDIAAVFG--------F--SG----A-S------D--PGVADLGAKVLAQIGVAVSHLG------D-E---GKMVAEMKA---VGVRH-KGYGYKHI-KAEYFEPLGASLLSAME-HR----I-GGKMTAAAKDAWAAA----YADISGALI-SG--L---------------------------------------------QS------
myo-polychaete ----M----------------------------A---------------------G---------------------------------------------LSGADIAVIRSTWAKVQGSG-SA---TDIGRSIFIKFFELDPAAQNEFP--------C--KG----E-SLAALKTN--VLLGQHGAKFMEYITTAVNGLD------DYA---GKAHGPLTE---LGSRH-KTRG---T-TPANFGKAGEALLAILA-SV----V-GGDFTPAAKDAWTKV----YNTISSTMQ-AA--L-----------------------------------------------------
leghemo-pea ----M--------------------------------------------------G---------------------------------------------FTEKQEALVNSSWELFK--Q-NP---SY-SVLFYTIILKKAPAAKGMFS--------F--LK----D-SA-EVVDS--PKLQAHAEKVFGMVHDSAIQLR------A-S---GEVVLGDAT---LGAIH-IQKG---V-VDPHFVVVKEALLETIK-EA----S-GEKWSEELSTAWEVA----YEGLASAIK-KA--M-----------------------------------------N-----------
leghemo-rice ----M-----------------ALVEDNNAVAV----------------------S---------------------------------------------FSEEQEALVLKSWAILK--K-DS---ANIALRFFLKIFEVAPSASQMFS--------F--LR----N-SDVPLEKN--PKLKTHAMSVFVMTCEAAAQLR------K-A---GKVTVRDTTLKRLGATH-LKYG---V-GDAHFEVVKFALLDTIK-EE----VPADMWSPAMKSAWSEA----YDHLVAAIK-QE--M-----------------------------------------KPAE--------
neuro-human ----M---------------ER----------------------------------------------------------------------------------PEPELIRQSWRAVS--R-SP---LEHGTVLFARLFALEPDLLPLFQ--------Y--NC-RQFS-SPEDCLSS--PEFLDHIRKVMLVIDAAVTNVE------D-L---SSLEEYLAS---LGRKH-RAVG---V-KLSSFSTVGESLLYMLE-KC----L-GPAFTPATRAAWSQL----YGAVVQAMS-RG--W----------------------------------DGE----------------
neuro-zebrafish ----M---------------EK-------------------------------------------------------------------------------LSEKDKGLIRDSWESLG--K-NK---VPHGIVLFTRLFELDPALLTLFS--------YSTNC----G-DAPECLSS--PEFLEHVTKVMLVIDAAVSHLD------D-L---HTLEDFLLN---LGRKH-QAVG---V-NTQSFALVGESLLYMLQ-SS----L-GPAYTTSLRQAWLTM----YSIVVSAMT-RG--W--------------------------------AKNGEHKSN------------
HbA-blood_clam ----M--------------------------------------------------A----------------------------DEEQIAKAVFKEAKALCDSDAAKENLRSSFKILA--N-DI---ESSGLQLMKNLFTSHPDTLGYFAR-------F--KD----V-SLG--KQN--WQLRGHAITLMYALMNFVDALD------E-P---DRLKCVVLK---FAVNH-NNRS---I-SPQVFGKINGPMDLLLK-QR----M-GKYYNRETANAWKQL----VGVVQAALT-TP--N-----------------------------------------------------
HbI-Lucina ----M--------------------------------------------------S---------------------------------------------LSAAQKDNVKSSWAKAS--A-AW---GTAGPEFFMALFDAHDDVFAKFSGL------F--KG----A-AKGTVKNT--PEMAAQAQSFKGLVSNWVDNLD------N-A---GALEGQCKT---FAANH-KARG---I-SAGQLEAAFKVLAGFMK-SY----G-G------DEGAWTAV----AGALMGMIR-PN--M-----------------------------------------------------
HbII-Lucina ----T--------------------------------------------------T---------------------------------------------LTNPQKAAIRSSWSKFM--D-NG---VSNGQGFYMDLFKAHPETLTPFKSL------F--GG----L-TLAQLQDN--PKMKAQSLVFCNGMSSFVDHLD------D-----NMLVVLIQK---MAKLH-NNRG---I-RASDLRTAYDILIHYME-DHNHMVG-G------AKDAWEVF----VGFICKTLG-DY--M-----------------------------------------------KELS--
myo-Dolabella -------------------------------------------------------A---------------------------------------------LSAAEAEVVAKSWGPVF--A-NK---DANGDNFLIALFEAYPDSPNFFAD-------F--KG----K-SIADIRAS--PKLRNVSSRIVSRLNEFVSSAA------D-A---GKMAAMLDQ---FSKEH-AGFG---V-GSQQFQNVSAMFPGFVA-SI----A-APPAG--ADAAWGKL----FGLIIDAMKKAG--K-----------------------------------------------------
myo-snail -------------------------------------------------------S---------------------------------------------LQPASKSALASSWKTLA--K-DAATIQNNGATLFSLLFKQFPDTRNYFTH-------F--GN----M-SDAEMKTT--GVGKAHSMAVFAGIGSMIDSMD------D-A---DCMNGLALK---LSRNH-IQRK---I-GASRFGEMRQVFPNFLD-EA----L-GGGASGDVKGAWDAL----LAYLQDNKQAQA--L-----------------------------------------------------
drosophila ----M-------------------------------------------------------------------------------------------------NSDEVQLIKKTWEIPV--A-TP---TDSGAAILTQFFNRFPSNLEKFP--------F--RD----V-PLEELSGN--ARFRAHAGRIIRVFDESIQVLG---QDGD-L---EKLDEIWTK---IAVSH-IPRT---V-SKESYNQLKGVILDVLT-AA----C-SLDES--QAATWAKLVDHVYAIIFKAID-DDGNA-----------------------------------------------------
midge-8 AVTPM-------------------------------------------------------------------------------------------------SADQLALFKSSWNTVK--H-NE-------VDILYAVFKANPDIQAKFPQ-------F--AG----K-DLDSIKDS--ADFAVHSGRIVGFFSEVIGLIG------N-PENRPALKTLIDG---LASSH-KARG---I-EKAQFEEFRASLVDYLS-HH----L-DWNDT--MKSTWDLALNNMFFYILHALE-VA--Q-----------------------------------------------------
honeybee ----M-----------------------------GTFLRFLGISSSDDNRIDQATG---------------------------------------------LTERQKKLVQNTWAVVR--K-DE---VASGIAVMTAFFKKYPEYQRYFTA-------F--MD----T-PLNELPAN--KRFQAHCAGVITALNNVIDFLH------D-P---GLMEASLIG---LVERH-KKRG---Q-TKEEFQNLKEVMLEVLR-QA----L-GKQYTPEVAEAWNKTLDMMFGKIYQVFA-S---------------------------------------------------------
beetle ----M-----------------------------GQLISLYKYYTTRTDDPDPLTT---------------------------------------------LTSREVFLVQSSWDPIK--K-DL---TGYGVQLLLFLFKKYPEEQQNFP--------F--RD----M-PFEELGAS--KKFHAHCSNVMYAVDSIIDSLK------D-G---ELLVNILEK---IGRNH-HRNT---V-KPISFWHVKETMLEFFK-KM----M-----NDETLKAWDKALQVAFGVVAKELD-KK--N-----------------------------------------------------
cyto-beetle ----M-----------------------------GIITSTLSYYMTKTNDPDPITG---------------------------------------------LTSRDRYVIQTSWAPVK--K-DL---TGNGVALLLLYFEKFPATKNYFV--------F--KD----V-PNEKLKTD--KKFHAHCNSVMVTLDSLIANLN------D-G---ELIVSLLEK---LGKNH-KRHG---I-KDDAYDQLKETVIELFS-SF----M-----TKEELETWDKLLKVAFSVIIKYL------------------------------------------------------------
cyto-fish ----M--------------------------------------------------SHREPPPPQLAVQRRDVDGQDGPERAEP------------------LSDTEREMIRDAWGHVY--K-NC---EDVGVSILIRFFVNFPSAKQYFSQ-------F--QD----MEEPEEMERS--SQLRHHACRVMNALNTVVENLH------D-P---EKVSSVLAV---VGRAHAVKHK---V-EPMYFKILSGVILEVLC-ED----F-PEFFTADVQLVWSKL----MATVYWHVT-GA--YTDVGWLQ-----------VSSSAV-----------------------------
cyto-human ----M-----------------------------------------------------EKVPGEMEIERR--------ERSEE------------------LSEAERKAVQAMWARLY--A-NC---EDVGVAILVRFFVNFPSAKQYFSQ-------F--KH----MEDPLEMERS--PQLRKHACRVMGALNTVVENLH------D-P---DKVSSVLAL---VGKAHALKHK---V-EPVYFKILSGVILEVVA-EE----F-ASDFPPETQRAWAKL----RGLIYSHVT-AA--YKEVGWVQQVPNATTPPATLPSSGP-----------------------------
hagfish ----MSAHGIA--------------------------------------------R---------------------------------------------TTEGERAAVRASWAVLM--K-DY---EHAGVQILDKFFKANPAAKPFFTK-------M--KD----LHTLEDLASS--ADARWHVERIIQAVNFAVINIE------D-R---EKLSNKFVK---LSQDHIEEFH---VTDPQYFMILSQTILDEV-EKR----N--GGLSGEGKSGWHKV----MTIICKMLK-SK--Y-----------------------------------------------------
lamprey ----M------PIVDSGSVP-----------------------------------A---------------------------------------------LTAAEKATIRTAWAPVY--A-KY---QSTGVDILIKFFTSNPAAQAFFPK-------F--QG----LTSADQLKKS--MDVRWHAERIINAVNDAVVAMD------D-T---EKMSLKLRE---LSGKHAKSFQ---V-DPQYFKVLAAVIVDTV-L--------PGD------AGLEKL----MSMICILLR-SS--Y-----------------------------------------------------
myo-human ----M--------------------------------------------------G---------------------------------------------LSDGEWQLVLNVWGKVE--A-DI---PGHGQEVLIRLFKGHPETLEKFDK-------F--KH----LKSEDEMKAS--EDLKKHGATVLTALGGILKK--KGH-----------HEAEIKP---LAQSHATKHK---I-PVKYLEFISECIIQVLQ-SK----H-PGDFGADAQGAMNKA----LELFRKDMA-SN--Y------------------------KELGFQG----------------------
myo-shark --------------------------------------------------------------------------------------------------------VDWEKVNSVWSAVE--S-DL---TAIGQNILLRLFEQYPESQNHFPK-------F--KN-----KSLGELKDT--ADIKAQADTVLSALGNIVKK--KGS-----------HSQPVKA---LAATHITTHK---I-PPHYFTKITTIAVDVLS-EM----Y-PSEMNAQVQAAFSGA----FKIICSDIE-KE--Y------------------------KAANFQG----------------------
hemo-alpha-human ----M--------------------------------------------------V---------------------------------------------LSPADKTNVKAAWGKVG--A-HA---GEYGAEALERMFLSFPTTKTYFPH-------F---D----LSH-----GS--AQVKGHGKKVADALTNAVAHVD------D-------MPNALSA---LSDLHAHKLR---V-DPVNFKLLSHCLLVTLA-AH----L-PAEFTPAVHASLDKF----LASVSTVLT-SK--Y-------------------------------R---------------------
hemo-alpha-shark -------------------------------------------------------V---------------------------------------------LSAADKTAIKHLTGSLR--T-NA---EAWGAESLARMFATTPSTKTYFSK-------F--TD----FSA-----NG--KRVKAHGGKVLNAVADATDHLD------N-------VAGHLDP---LAVLHGTTLC---V-DPHNFPLLTQCILVTLA-AH----L--TELKPETHCALDKF----LCEVATALG-SH--Y-------------------------------R---------------------
hemo-beta-human ----M--------------------------------------------------V---------------------------H-----------------LTPEEKSAVTALWGKV-----NV---DEVGGEALGRLLVVYPWTQRFFES-------F--GD----LSTPDAVMGN--PKVKAHGKKVLGAFSDGLAHLD------N-------LKGTFAT---LSELHCDKLH---V-DPENFRLLGNVLVCVLA-HH----F-GKEFTPPVQAAYQKV----VAGVANALA-HK--Y-------------------------------H---------------------
hemo-beta-shark -------------------------------------------------------V---------------------------H-----------------WTGEEKALVNAVWTKT-----DH---QAVVAKALERLFVVYPWTKTYFVK-------F--NGK---FHA-------SDSTVQTHAGKVVSALTVAYNHID------D-------VKPHFVE---LSKKHYEELH---V-DPENFKLLANCLEVELG-HA----L-HKEFTPEVQAAWSKF----SNVVVDALS-KG--Y-------------------------------H---------------------